Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave Aurora, CO 80045


Shawn McCandless, MD

Clinical Biochemical Genetics

Board Certified


Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave, Aurora, CO 80045


Provider Expertise

Clinical Interest for Patients

I am a Clinical Geneticist, first and foremost, with special expertise and interest in inborn errors of metabolism, especially urea cycle disorders and fatty acid oxidation disorders, Prader-Willi syndrome, and generally, rare genetic disorders. Development of new approaches to management and treatment of genetic and metabolic disorders is a key to our practice, which is at the cutting edge where science and technology meet clinical care. The rapid translation of scientific advances to clinical care is at the heart of our team's work.

Care Philosophy

Most of us know that our genetic make-up is fundamental to how our body works, but when faced with the possibility of a genetic related disease, the implications can feel very frightening, complex and intense. A knowledgeable and kind professional can be incredibly helpful at that time to understand complex risks and healthcare decisions. Our team takes a holistic approach to the needs of the individual and the family. At the same time, having an expert in rare diseases, someone who has heard of, and knows about, the condition you are facing, is helpful and important. We know that genetic conditions can be managed, treated, and outcomes can improve.


  • Clinical Genetics and Genomics (MD)
  • Clinical Biochemical Genetics ( 2005 , 2022 )

Conditions & Treatments

  • Food, Nutrition and Metabolism

  • Genetic Conditions and Testing

Education & Training

Medical Schools

MD, Temple University School of Medicine (1988)

Undergraduate Schools

BS, Westminster College (PA) (1984)

Residency Program

University Hospitals Case Medical Center Program (1999)

University of Wisconsin Hospital and Clinics Program (1991)


University Hospitals Case Medical Center Program (2005)

Professional Memberships

American College of Medical Genetics and Genomics, Member

American Society for Human Genetics, Member

Society for Inherited Metabolic Disorders, Former President

information for referring providers

Referral Contact Phone


Clinical Interests for Referring Providers

Inborn errors of metabolism, particularly urea cycle disorders and fatty acid oxidation disorders; mitochondrial disease; Prader-Willi syndrome; therapy for genetic disorders, development of novel therapies including N of 1 treatment plans

Research Interest for Referring Providers

My research now focuses primarily on the development of novel treatments for genetic disorders and clinical trials for inborn errors of metabolism, Prader-Willi syndrome, and other rare genetic disorders; I am also particularly interested in approaches to newborn screening as well as the philosophy, structure and challenges to newborn screening systems in the U.S.