Practice Locations

UCHealth Anschutz Inpatient Pavilion - Anschutz Medical Campus
12605 E. 16th Ave Aurora, CO 80045


Clay Smith, MD


Board Certified


Practice Locations

UCHealth Blood Disorders and Cell Therapies Center - Anschutz Medical Campus
1665 Aurora Court, 3rd floor, Anschutz Cancer Pavilion, Aurora, CO 80045


UCHealth Anschutz Inpatient Pavilion - Anschutz Medical Campus
12605 E. 16th Ave Aurora, CO 80045


Provider Expertise

Clinical Interest for Patients

Personalized medicine

Care Philosophy

I'm keen to see persons with blood cancers get the latest in treatment advances as well as the most compassionate and supportive care.


  • Hematology ( 1994 , 2016 )
  • Internal Medicine ( 1989 )

Conditions & Treatments

  • Cancers

    Blood and Marrow Transplant, Leukemia (Adult Acute)

Interests & Activities

Personal Interests

Dr. Smith received his bachelor’s degree from Rice University and his MD from University of Texas, Southwestern Medical School where he also completed his internship. The majority of his post-graduate training was completed in New York City, with residency at NY Hospital/Cornell Medical Center and a fellowship in Hematology and Oncology at Memorial Sloan Kettering Cancer Center. He performed advanced fellowship training in bone marrow transplantation (BMT) at Stanford University. Dr. Smith’s first faculty appointment was as an Assistant Professor at Duke University where he established a highly successful research program specifically focused on gene transfer strategies for therapeutic modification of hematopoietic cells (HSCs) and novel methods of high throughput flow cytometric analysis. Dr. Smith has also served in appointments with the Moffitt Cancer Center, the University of British Columbia, Vancouver, and University of Pittsburgh. Throughout the course of his career, Dr. Smith has published over 150 scientific articles. He was recruited to serve as the program director of the Blood Cancer & BMT Program at the University of Colorado in 2012, and currently is the Associate Chief of the Division of Hematology and the Medical Director of the Innovation Centers at CU and UCHealth.

Education & Training

Medical Schools

MD, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School (1984)

Undergraduate Schools

BA, Rice University (TX) (1979)


Parkland Memorial Hospital, Dallas, Texas (1985)

Residency Program

New York Presbyterian Hospital (Cornell Campus) Program (1987)


Memorial Sloan-Kettering Cancer Center Program (1992)

Research & Grants

Research Interests for Patients

My research is focused on precision medicine for hematologic malignancies

information for referring providers

Referral Contact Phone

(720) 848-6400

Clinical Interests for Referring Providers

Hematologic malignancies, blood and marrow transplant, cellular therapies

Research Interest for Referring Providers

Dr. Smith’s research has been devoted to the advancement of care for persons with blood cancers through integrating advances in laboratory, clinical and informatics technologies and research. He currently focuses on using multi-comics and advanced computational analytics to direct patients with blood cancers to best available therapies as well as identifying new potential avenues of therapy.