Research Interests for Patients

My early scholarship focused on pharmacokinetics and advanced bioanalytical assay development using LC-MS/MS methodologies. I contributed to the development and validation of highly sensitive assays for opioids, immunosuppressants, and other therapeutic agents in plasma, whole blood, and dried blood spots, supporting advances in therapeutic drug monitoring and pediatric pharmacology. This work evolved into clinical pharmacology investigations examining opioid metabolism, intranasal fentanyl for breakthrough pain, extended-release epidural morphine, methadone quantification, and ondansetron pharmacokinetics in pregnant women and neonates. My research portfolio subsequently expanded to perioperative outcomes and neuroanesthesia, with particular emphasis on spine surgery, intraoperative neurophysiologic monitoring (IONM), and patient safety. I have contributed to consensus guidelines optimizing anesthetic management for transcranial motor evoked potential monitoring in complex spine surgery and have led or collaborated on studies examining toxicology screening in spine patients, postoperative cognitive dysfunction, obstructive sleep apnea and surgical risk, standardized neuromonitoring protocols, and intraoperative hemodynamic optimization. More recently, my work has incorporated systems-level and equity-focused research, including language proficiency and postoperative pain management.