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Practice Locations

National Jewish Health
1400 Jackson St Denver, CO 80206

1-877-225-5654

Amen Sergew, MD

Pulmonary Disease and Critical Care Medicine

Board Certified

Schedule Appointment

Amen Sergew, MD

Provider

Board Certified

GENDER

Female

LANGUAGE

English

DEPARTMENT

Medicine

Specialty

Pulmonary Disease and Critical Care Medicine

Primary Clinic Phone

(303) 398-1511

Locations

Practice Locations

National Jewish Health
1400 Jackson St Denver, CO 80206

1-877-225-5654

Clinical Interest for Patients

I am interested in treating Allergies, Asthma, Autoimmune Lung Diseases, Cystic Fibrosis, Chronic Respiratory Failure, COPD, Environmental and Occupational Medicine, Eosinophilic Lung Diseases, Hypersensitivity Pneumonitis, Interstitial and Fibrotic Lung Disease, Lung Cancer, Lymphangioleiomyomatosis (LAM), Malignant Pleural Effusions, Pulmonary Alveolar Proteinosis, Pulmonary Hypertension, Respiratory Infections, Sleep Disorders and Vocal Cord Dysfunction.


Specialties

  • Pulmonary Disease and Critical Care Medicine

Conditions & Treatments

  • Brain and Nervous System

    Sleep Disorders

  • Immune System

    Allergies

  • Lungs and Breathing

    Asthma, Interstitial Lung Disease, Lung Disease

Medical Schools

MD, University of North Carolina at Chapel Hill School of Medicine (2002)


Undergraduate Schools

BA, University of North Carolina–Charlotte (NC) (1995)

BS, University of North Carolina–Chapel Hill (NC) (1997)


Internships

University of Minnesota Medical School Program (2003)


Residency Program

University of Minnesota Program (2005)


Fellowships

University of Colorado (2009)

American College of Chest Physicians, Member


American Thoracic Society (ATS), Member


Faculty of 1000 Medicine, Associate Faculty Member


Research Interests for Patients

I am interested in idiopathic pulmonary fibrosis.

information for referring providers

Clinical Interests for Referring Providers

I am interested in treating Allergies, Asthma, Autoimmune Lung Diseases, Cystic Fibrosis, Chronic Respiratory Failure, COPD, Environmental and Occupational Medicine, Eosinophilic Lung Diseases, Hypersensitivity Pneumonitis, Interstitial and Fibrotic Lung Disease, Lung Cancer, Lymphangioleiomyomatosis (LAM), Malignant Pleural Effusions, Pulmonary Alveolar Proteinosis, Pulmonary Hypertension, Respiratory Infections, Sleep Disorders and Vocal Cord Dysfunction.

Research Interest for Referring Providers

Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease characterized by uncontrolled chronic fibrosis of the lung parenchyma. In usual interstitial pneumonia (UIP) there is a notable lack of inflammatory cells. The role of inflammation has often been the subject of study with no clear answer. To address this question, my project focuses on the role of mitogen-activated protein kinases (MAPK) in IPF. MAPK are a family of highly conserved kinases that are important in the inflammatory response, as well as apoptosis, immune responses and other cellular processes. Feedback control of MAPK occurs through MAPK phosphatases (MKP). MKP-1 is the archetypal MKP and plays a role in regulating JNK and p38. MKP-1 null alveolar macrophages have an increased inflammatory response to LPS stimulation. My research focuses on the affects of MKP-1 on lung fibrosis in response to intratracheal bleomycin in mice. Compared to wild type mice, bleomycin-instilled MKP-1 null and heterozygote mice exhibit: (i) a less fibrotic pattern of injury, (ii) decreased total lung collagen accumulation and (iii) normal lung elasticity. To understand the mechanism behind this phenotype, I am now evaluating apoptosis assays in fibroblasts, bone marrow chimeric studies to assess stromal versus hematopoietic source for the phenotype, and evaluating differences in cell types and cytokines between MKP nulls and wild types.


Referral Contact Phone: (303) 398-1511